New study on function of DNMT3A variant

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05/08/20

New study on function of DNMT3A variant

Researchers at the University of California, Riverside, have examined the function of a particular mutation in the DNMT3A gene called R882H. This variant is a common driver of acute myeloid leukemia in people who do not have TBRS, and some individuals with TBRS have this same genetic sequence. The scientists found that the R882H variant reduces the activity of the DNMT3A protein and also causes it to behave abnormally.

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