Collaborative Research Network Conference

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11/12/20 - 11/13/20

Collaborative Research Network Conference

Scientists are clinicians will gather for the first meeting devoted to TBRS, DNMT3A, and related topics.

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Event
Virtual
11/12/20 - 11/13/20
2 Days
9:00 AM - 2:00 PM

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The TBRS Community is organizing the first-ever TBRS Collaborative Research Network Conference. This virtual event will feature presentations by scientists and clinicians who are experts on TBRS, DNMT3A (the gene that causes TBRS), overgrowth and neurodevelopmental disorders, and related topics.

The goals of the meeting are to foster discussion among this group of scholars and develop research priorities for understanding and, ultimately, treating TBRS.

With a generous grant from the National Organization for Rare Disorders, The TBRS Community has hired a virtual conference vendor to facilitate the production of presentations and host the event. The conference will be held over two days and will be a mix of pre-recorded talks, live Q&As, and open discussion forums. To encourage collaboration and allow for the presentation of preliminary data and work in progress, this event is not open to the public.

Please email tbrscrn@tbrsyndrome.org if you would like an invitation to the meeting.

Collaborative Research Network Conference 2020

November 12-13, 2020

November 12th 9 AM to 1:30 PM (all US Eastern Time Zone)

I. 9:00 – 9:45 AM: Introduction and Plenary Talk

9:00-9:10 Welcome Message – Jill Kiernan, President, The TBRS Community

9:10-9:35 Plenary talk by Dr. Kate Tatton-Brown, St. George’s Hospital:

“DNMT3A and TBRS: the journey from gene discovery to syndrome delineation”

9:35-9:45 Q&A Discussion

II.9:45 – 10:45 AM: Session 1 – Clinical Aspects of TBRS 

Session Chair: Dr. Kate Tatton-Brown, St. George’s Hospital

9:45-9:50 Session introduction by Dr. Kate Tatton-Brown

9:50-10:15 Talk 1 – Dr. Marwan Shinawi, Washington University School of Medicine: “Clinical and genetic aspects of TBRS,” followed by Q&A

10:20-10:45 Talk 2 – Dr. Rosanna Weksberg, The Hospital for Sick Children: “Overgrowth syndromes: Lessons from DNA methylation studies,” followed by Q&A

III. 10:45 – 11:00 AM: Coffee Break

IV. 11:00 – 12:30 PM: Session 2 – Molecular Aspects of TBRS

Session Chair: Dr. Ayala Tovy, Baylor College of Medicine

11:00-11:05 Session introduction by Dr. Ayala Tovy

11:05-11:30 Talk 1 – Dr. Ayala Tovy, Baylor College of Medicine: “The multifaceted function of DNMT3A in TBRS associated phenotypes,” followed by Q&A

11:35-12:00 Talk 2 – Dr. Chao Lu, Columbia University: “Interplay between DNA and histone methylation in developmental overgrowth syndromes,” followed by Q&A

12:05-12:30 Talk 3 – Dr. Jikui Song, University of California, Riverside: “DNMT3A-mediated DNA methylation in health and disease: a structural perspective,” followed by Q&A

V. 12:30 – 12:50 PM: Lunch Break & Topic Submissions for General Discussion

VI. 12:50 – 1:00 PM: Community Priorities Survey Results Presentation by Dr. Vicken Totten

VII. 1:00 – 1:30 PM: General Discussion Moderated by Kerry Grens, Vice President, The TBRS Community

November 13th 9 AM to 1:30 PM (all US Eastern Time Zone)

I. 9:00 – 9:10 AM: Introduction 

9:00-9:10 Welcome Message - Jill Kiernan, President, The TBRS Community

II. 9:10 – 11:10 AM: Session 3 – Neurodevelopmental & Psychiatric Aspects of TBRS

Session Chair: Dr. Harrison Gabel, Washington University in St. Louis

9:10-9:15 Session introduction by Dr. Harrison Gabel

9:15-9:40 Talk 1 – Dr. Harrison Gabel, Washington University: “Defining the impact of DNMT3A mutation on the neuronal epigenome,” followed by Q&A

9:45-10:10 Talk 2 – Dr. Pablo Lapunzina, CIBERER: “Clinical findings in patients with TBRS,” followed by Q&A

10:15-10:40 Talk 3 – Dr. Ana Oliveira, University of Heidelberg: “DNMT3A role in cognitive abilities,” followed by Q&A

10:45-11:10 Talk 4 – Dr. Qingchun Tong, University of Texas Health Science Center: “A novel neurocircuit for emotional feeding,” followed by Q&A

III. 11:10 – 11:25 AM: Coffee Break

IV. 11:25 – 12:25 PM: Session 4 – Malignancy

Session Chair: Dr. Tim Ley, Washington University School of Medicine

11:25-11:30 Session introduction by Tim Ley

11:30-11:55 Talk 1 – Dr. Tim Ley, Washington University School of Medicine: “DNMT3A mutations and leukemia risk,” followed by Q&A

12:00-12:25 Talk 2 – Dr. Amanda Smith, Washington University School of Medicine: “Characterizing the epigenome of TBRS,” followed by Q&A

V. 12:25 – 12:45 PM: Lunch Break & Topic Submissions for General Discussion

VI. 12:45 – 1:30 PM: Research Priorities Discussion Moderated by Kerry Grens, Vice President, The TBRS Community